Pathogenesis of cancer

CONCLUSIONS

Based on the above, the following conclusions can be drawn:

1. The precursor cell of the primary malignant stem cell of solid tumors is a tissue mononuclear cell (Monocyte), which has genotypic and epigenetic changes.

2. The primary mutation of the nuclear DNA of the Monocyte genome occurs in the red bone marrow after the carcinogenic effects of the initiator (ionizing radiation, endo- and exocarcinogens).

3. From the red bone marrow, the monocyte enters the bloodstream, where it remains from 36 to 104 hours (1.5 – 4.5 days), and then leaves it according to a stochastic principle, migrating to the focus of chronic inflammation.

4. The primary mutation of the nuclear DNA of the Monocyte genome can be determined using sequencing, after isolating the Monocyte from the circulating blood of a person with a solid malignant tumor.

5. Knowing the primary mutation of the nuclear DNA of the Monocyte genome, as a precursor cell of a cancer cell, it is possible to create a therapeutic anti-cancer DNA vaccine “on demand”.

6. The basis for the “generation” of a malignant stem cell is the return of a tissue mononuclear cell, which has genotypic and epigenetic changes, to the embryonic state during mitosis, a differentiation block at the pluripotent or unipotent level and transformation.

7. The mechanism of “generation” of a malignant stem cell is a complex multi-stage process, when mutations in the nuclear DNA of a bone marrow mononuclear cell successively appear under carcinogenic influence and epigenetic changes in the same, but tissue mononuclear cell under the influence of “super conditions” of an isolated microcavity, and mitosis is the starting point for their implementation.

8. Initially, this will be an “on demand” vaccine, then it is possible to use a vaccine based on a set of primary mutations in the nuclear DNA of the genome of the progenitor cell of the cancer cell.

LITERATURE:

1. Shalin S.A., Keskinov A.A. Mononuclear opcogenesis. 2010, 146 pp.

2. Bozhenkov Yu.G., Shcherbyuk A.N., Shalin S.A. Practical pancreatology. Guide for doctors. MIG “Medical Book”, 2002, 112-137 pp.

3. Abelev G.I., Altshtein A.D., Deigman G.I., Dyban P.A. and others. Tumor growth as a problem in developmental biology. M., “Science”, 1979, 244 pp.

4. Abramov M.G. Hematological atlas. M., Medicine, 1985, 344 pp.

5. Almazov I.V., Sutulov L.S. Atlas of histology and embryology. M., Medicine, 1978, 544 pp.

6. Atlas of blood cells and bone marrow. /Edited by G.I.Kozints/. "Triad-X", M., 1998, 160 pp.

7. Afanasyev B.V., Almazov V.A. Progenitor hematopoietic cells in humans. L., “Science”, 1985, 204 pp.

8. Belokhvostov A.S., Novik A.A. The role of molecular genetic studies in the diagnosis of solid tumors. "Oncology Issues". T.45, No. 6, 1999, pp. 599-606. 9. Bzhadug O.B., Grivtsova L.Yu., Tupitsin N.N., Tyulyandin S.A. Circulating tumor cells in the blood of patients with locally advanced and disseminated breast cancer. “Bulletin of the Russian Oncology Research Center named after N.N. Blokhin”, T. 18, No. 3, 2007, pp. 19-21.

10. Bilibin D.P., Babichenko I.I., Khodorovich N.A. Pathophysiological and pathomorphological aspects of acute and chronic inflammation. M., Publishing house of the Russian Peoples' Friendship University. 2003, 35 pp.

11. Bochkov N.P. Clinical genetics. Textbook. M., GEOTAR-med, 2002.

12. Bykorez A.I., Rubenchik B.M. Causes of cancer: facts and hypotheses. Kyiv, Naukova Dumka, 1987, 118 pp.

13. Vakhtin Yu.B., Pinchuk V.K., Schwemberger I.N., Butenko Z.A. Clonal selection concept of tumor growth. Kyiv. Naukova Dumka, 1987, 215 pp.

14. Vladimirskaya E.B. Biological basis of antitumor therapy. M., Agat-Med, 2001, 110 pp.

15. Vorobyov A.I. Guide to histology. M., Medicine, T.1, 1985, 447 pp.

16. Galankin V.N., Tokmakov A.M. Problems of inflammation from the perspective of theory and clinic. M., Peoples' Friendship University Publishing House, 1991, 120 pp.

17. Garin A.M., Bazin I.S. The ten most common malignant tumors. M., KMN Agency, 2006, 266 pp.

18. Gerasimov I.G., Popandopulo A.G. Assessment of cell viability based on their morphometric parameters using the example of cultured fibroblasts. Cytology. 2007, T.49, No. 3, pp. 204-209.

19. Histology, cytology and embryology. /Edited by Yu.I.Afanasyev, N.A.Yurina/. M., Medicine, 2002, 737 pp.

20. Histology. /Edited by E.G. Ulumbekov, prof. Yu.A. Chelysheva/. M., GEOTAR-MED, 2001, 672 pp.

21. Gorbunova V.N., Imyanitov E.N. Genetics and carcinogenesis. Toolkit. St. Petersburg, SPbGPMA, 2007, 24 pages.

22. Granov A.M., Shutko A.N. Paradoxes of malignant growth and tissue incompatibility. St. Petersburg, Hippocrates Publishing House, 2002, 223 p. 23. Grigoryan A.S. The role of the SDF-1-CXCR4 migratory axis in the homing of malignant tumor progenitor cells. Cell Transplantation and Tissue Engineering, 2006. 4 (6): 32-7.

24. Green N., Stout W., Taylor D. Biology. M., "Mir", T.1, 1990, 367 pp.

25. Davydov M.I., Demidov L.V., Polyakov B.I. Fundamentals of modern oncology. M., 2002, 237 pp.

26. Danilov R.K., Klimov A.A., Borovaya T.G. Histology. ELBI-SPB, St. Petersburg, 2003, 360 pp.

27. Zholondz M.Ya. Cancer. Myths, theory, prevention. Set, S.-P., 1998, 335 pp.

28. Zaichik A.Sh., Churilov L.P. Mechanisms of development of diseases and syndromes. St. Petersburg, "ELBI-SPb", 2005, 507 pp.

29. Malignant tumors. Clinical guidelines. /Edited by N.N.Petrov, S.A.Kholdin/. L., MEDGIZ, 1952, T.2. 944 pp.

30. Ivanov K.P. Basics of body energy. T.1, L., “Science”, 1990, 307 pp.

31. Ivashkin V.T., Vasiliev V.Yu., Severin E.S. Levels of regulation of the functional activity of organs and tissues. L., “Science”, 1987, 272 pp.

32. Ivashchenko Yu.D., Bykorez A.I. Polypeptide factors and carcinogenesis. Kyiv, Naukova Dumka, 1990, 192 pp.

33. Imyanitov E.N., Hanson K.P. Molecular oncology: clinical aspects. St. Petersburg, SPbMAPO, 2007, 213 pp.

34. Kalishevskaya T.M., Kolomina S.M., Kudryashov B.A. Blood coagulation and anticoagulation systems and their significance in the development of malignant neoplasms. M., Moscow University Publishing House, 1992, 167 pp.

35. Carcinogenesis. /Ed. D.G.Zaridze/. M., "Scientific World". 2000, 420 pp. 36. Kiselev F.L., Pavlish O.A., Tatosyan A.G. Molecular basis of carcinogenesis in humans. M., Medicine, 1990, 316 pp.

37. Knorre A.G. Embryonic histogenesis. 1971.

38. Kraevsky A.N., Smolyannikov A.V., Sarkisrv D.S. Pathological diagnosis of human tumors. T.1, M., Medicine, 1993, 559 pp.

39. Krivchik A.A. Pathophysiological aspects of tumor growth. Minsk, “Higher School”, 1987, 143 pp.

40. Lugovskaya S.A., Pochtar M.E. Hematological atlas. M.,"Triad", 2004, 227 pp.

41. Makarenko N.P. Fibrocystic disease. "Oncology", T. 13, No. 13, 2005, pp. 875-877. 42. Marie E. Wood, Paul A. Bunn. Secrets of hematology and oncology. Translation from English. M., Publishing house "BINOM", 2001, 559 pp.

43. Mayansky D.N. Chronic inflammation. M., Medicine, 1991, 271 pp.

44. Mekler L. B. Mechanisms of tumor induction in the light of the general theory of oncogenesis. – Advances in modern biology, 1978, 85, issue 1.

45. Morozkina T.S. Energy metabolism and nutrition in malignant neoplasms. Minsk, “Belarus”, 1989, 190 pp.

46. Pathological physiology. /Edited by A. D. Ado, L. M. Ishimova/. M.: Medicine, 1980.

47. Pathological diagnosis of human tumors./Edited by I.A. Kraevsky, A.V. Smolyaninov, D.S. Sarkisov/. T. 1-2, M., Medicine, 1993.

48. Peterson B.E., Chissova V.I. Early oncological pathology. M., Medicine, 1985, 316 pp.

49. Petrova A.S. Cytological diagnosis of tumors and pretumor processes. M., Medicine, 1985, 302 pp.

50. Practical oncology: selected lectures. /Edited by S.A.Tyulyandin, V.M.Moiseenko/. St. Petersburg, "TOMM Center", 2004, 784 pp.

51. Raikhlin N.T., David R., Lapish K. Ultrastructure of human tumors. Diagnostic guide. M., Medicine, 1981, 550 pp.

52. Wounds and wound infection. /Edited by M.I.Kuzin, B.M.Kostyuchenok/. M., medicine, 1990, 591 pp.

53. Repin V.S., Rzhaninova A.A., Shamenkov D.A. Embryonic stem cells: fundamental biology and medicine. M., "Remetex", 2002, 176 pp.

54. Terentyeva N.A., Alyasova A.V., Shakhov B.E. Hodgkin's lymphoma. Nizhny Novgorod. Publishing house "NizhSMA", 2008, 431 pages.

55. Tereshchenko I.P., Kashulina A.P. Pathophysiological aspects of malignant growth. M., Medicine, 1983, 255 pp.

56. Tokin B.P. General embryology. M., Medicine, 1987, 480 pp.

57. Trapeznikov N.N., Solovyov Yu.N., Shingarov G.Kh. Methodological issues in the study of oncogenesis. M., Medicine, 1988, 206 pp.

58. Truman D. Biochemistry of cell differentiation. Translation from English. M., Mir, 1976, 188 pp.

59. Frankfurt O.S. Cell cycle in tumors. M., Medicine, 1975, 170 pp.

60. Khodosova I.A. Biochemical aspects of carcinogenesis. M., Nauka, 1976, 205 pp. 61. Ham A., Cormack D. Histology. T. 1-5. Translation from English. M., "Mir", 1982. 62. Shapot V.S. Biochemical aspects of tumor growth. M., Medicine, 1975, 304 pp. 63. Shimke R.N. Genetics and cancer in humans. Translation from English. M., Medicine, 1981, 183 pp.

64. Shchelkunov S.I. Cytological and histological analysis of the development of normal and malignant structures. L., Medicine, 1971, 399 pp.